巨噬细胞清道夫受体SR-AI/II与肺部对肺炎球菌及颗粒的防御作用。
The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles.
作者信息
Arredouani Mohamed S, Yang Zhiping, Imrich Amy, Ning Yaoyu, Qin Guozhong, Kobzik Lester
机构信息
Physiology Program, 665 Huntington Avenue, SPH-II, Room 221, Boston, MA 02115, USA.
出版信息
Am J Respir Cell Mol Biol. 2006 Oct;35(4):474-8. doi: 10.1165/rcmb.2006-0128OC. Epub 2006 May 4.
Abstract
The class A macrophage scavenger receptor SR-AI/II is implicated as a pattern recognition receptor for innate immunity, but its functional role in lung defense has not been studied. We used mice genetically deficient in SR-AI/II and their wild-type C57BL/6 counterparts to investigate the contribution of this receptor to defense against pneumococcal infection and inhaled particles. SR-AI/II deficiency caused impaired phagocytosis of fluorescent bacteria in vivo, diminished clearance of live bacteria from the lungs, and substantially increased pneumonic inflammation. Survival studies also showed increased mortality in SR-AI/II-deficient mice with pneumococcal lung infection. Similarly, after challenge of the airways with TiO(2) particles, SR-AI/II-deficient mice showed increased proinflammatory cytokine levels in lung lavage fluid and a more pronounced neutrophilic inflammation. The data indicate that the lung macrophage class A scavenger receptor SR-AI/II contributes to innate defense against bacteria and inhaled particles.
摘要
A类巨噬细胞清道夫受体SR-AI/II被认为是一种参与固有免疫的模式识别受体，但其在肺部防御中的功能作用尚未得到研究。我们使用基因敲除SR-AI/II的小鼠及其野生型C57BL/6对照小鼠，来研究该受体在抵御肺炎球菌感染和吸入颗粒方面的作用。SR-AI/II基因缺陷导致体内荧光细菌的吞噬作用受损，肺部活菌清除能力下降，并显著加剧肺部炎症。生存研究还显示，患有肺炎球菌肺部感染的SR-AI/II基因缺陷小鼠死亡率增加。同样，在用TiO(2)颗粒攻击气道后，SR-AI/II基因缺陷小鼠肺灌洗液中的促炎细胞因子水平升高，中性粒细胞炎症更为明显。这些数据表明，肺部巨噬细胞A类清道夫受体SR-AI/II有助于对细菌和吸入颗粒的固有防御。
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本文引用的文献
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J Biol Chem. 2006 Apr 28;281(17):11834-45. doi: 10.1074/jbc.M507599200. Epub 2006 Jan 6.
2
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J Immunol. 2005 Dec 15;175(12):8032-41. doi: 10.4049/jimmunol.175.12.8032.
3
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J Immunol. 2005 Nov 1;175(9):6058-64. doi: 10.4049/jimmunol.175.9.6058.
4
The structure and function of marco, a macrophage class a scavenger receptor.巨噬细胞A类清道夫受体marco的结构与功能
Cell Mol Biol (Noisy-le-grand). 2004;50 Online Pub:OL657-65.
5
Air pollution and health - good news and bad.空气污染与健康——有好消息也有坏消息。
N Engl J Med. 2004 Sep 9;351(11):1132-4. doi: 10.1056/NEJMe048182.
6
Scavenger receptor A mediates H2O2 production and suppression of IL-12 release in murine macrophages.清道夫受体A介导小鼠巨噬细胞中过氧化氢的产生及白细胞介素-12释放的抑制。
J Leukoc Biol. 2004 Nov;76(5):1066-74. doi: 10.1189/jlb.0504270. Epub 2004 Aug 17.
7
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8
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9
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10
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