Handler William B, Gilbert Kyle M, Peng Hao, Chronik Blaine A
Department of Physics and Astronomy, University of Western Ontario, London, ON N6A 3K7, Canada.
Phys Med Biol. 2006 May 21;51(10):2479-91. doi: 10.1088/0031-9155/51/10/008. Epub 2006 Apr 26.
Mixing the imaging modalities of positron emission tomography (PET) and magnetic resonance imaging (MRI) will offer the best soft tissue contrast (MRI) with information about metabolic function (PET). The high magnetic field environment of an MRI system makes the detection of annihilation photons difficult, as the response of standard photo-multiplier tubes is compromised. An approach using field-cycled MRI is discussed here, as field-cycled MRI makes it possible to have long periods of time available for nuclear imaging when there is no magnetic field present. This work focuses upon the effect of the field-cycled MRI upon the nuclear image due to the added material providing additional attenuation of the PET signal, and additional nuclei for scatter. These effects are studied using a Monte Carlo simulation based upon the GEANT libraries. Attenuation effects are shown to be significant, approximately 6% for the RF shield and coil and approximately 24% for the gradients. No significant effect is seen in image quality due to the scattering of the gammas. With these levels of attenuation it is concluded that open gradient coils and shim coils are required around the imaging volume.
将正电子发射断层扫描(PET)和磁共振成像(MRI)这两种成像方式相结合,能够在提供代谢功能信息(PET)的同时,实现最佳的软组织对比度(MRI)。MRI系统的高磁场环境使得探测湮灭光子变得困难,因为标准光电倍增管的响应会受到影响。本文讨论了一种使用场循环MRI的方法,因为场循环MRI使得在无磁场存在时,有较长时间可用于核成像。这项工作聚焦于场循环MRI对核图像的影响,这是由于添加的材料会对PET信号产生额外衰减,并产生额外的用于散射的原子核。这些影响通过基于GEANT库的蒙特卡罗模拟进行研究。结果表明,衰减效应显著,射频屏蔽和线圈的衰减约为6%,梯度的衰减约为24%。由于伽马射线的散射,未观察到对图像质量有显著影响。基于这些衰减水平,得出结论:在成像区域周围需要开放式梯度线圈和匀场线圈。