Schroeder Jane C, Bensen Jeannette T, Su L Joseph, Mishel Merle, Ivanova Anastasia, Smith Gary J, Godley Paul A, Fontham Elizabeth T H, Mohler James L
Department of Epidemiology, UNC Linebarger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 1700 Airport Road, Chapel Hill, NC 27599, USA.
Prostate. 2006 Aug 1;66(11):1162-76. doi: 10.1002/pros.20449.
The North Carolina-Louisiana Prostate Cancer Project (PCaP) is a multidisciplinary study of social, individual, and tumor-level causes of racial differences in prostate cancer aggressiveness.
A population-based sample of incident prostate cancer cases from North Carolina and Louisiana will include 1,000 African Americans and 1,000 Caucasian Americans. Study nurses administer structured questionnaires and collect blood, adipose tissue, urine, and toenail samples during an in-home visit. Clinical data are abstracted from medical records, diagnostic biopsies are reviewed and assayed, and tissue microarrays are constructed from prostatectomy samples. Prostate cancer aggressiveness is classified based on PSA, clinical stage, and Gleason grade.
Preliminary data demonstrate between- and within-group differences in patient characteristics, screening, and treatment by race and state. Participation exceeds 70% in all groups.
Preliminary data support the feasibility of this comprehensive study to help determine the focus of public health efforts to reduce racial disparities in prostate cancer mortality.
北卡罗来纳州 - 路易斯安那州前列腺癌项目（PCaP）是一项关于前列腺癌侵袭性种族差异的社会、个体和肿瘤层面原因的多学科研究。
从北卡罗来纳州和路易斯安那州选取的基于人群的新发前列腺癌病例样本将包括1000名非裔美国人和1000名白人美国人。研究护士在上门访视期间发放结构化问卷，并采集血液、脂肪组织、尿液和趾甲样本。临床数据从医疗记录中提取，对诊断性活检进行复查和检测，并从前列腺切除样本构建组织微阵列。前列腺癌侵袭性根据前列腺特异性抗原（PSA）、临床分期和 Gleason 分级进行分类。
初步数据显示，在患者特征、筛查以及按种族和州划分的治疗方面，组间和组内存在差异。所有组的参与率均超过70%。
初步数据支持这项综合研究的可行性，该研究有助于确定公共卫生工作的重点，以减少前列腺癌死亡率方面的种族差异。
