David Geffen School of Medicine, University of California, Los Angeles, California 90095-1736, USA.
Nutr Cancer. 2012;64(5):637-42. doi: 10.1080/01635581.2012.676144. Epub 2012 May 7.
This study evaluated the relationship between caffeinated and decaffeinated coffee and prostate cancer (CaP) aggressiveness using data from a population-based incident CaP study within the North Carolina-Louisiana Prostate Cancer Project (PCaP). Classification of CaP aggressiveness at diagnosis was based on clinical criteria for 1,049 African-American (AA) and 1,083 Caucasian-American (CA) research subjects. Coffee consumption was measured using a modified NCI Dietary History Questionnaire. No significant associations were found between CaP aggressiveness and consumption of either caffeinated or decaffeinated coffee. The OR for high aggressive CaP among consumers of more than 4 cups per day was 0.92 (95%CI = 0.61, 1.39), compared to non-coffee-drinkers. Results stratified by race found no significant associations and no noticeable trends in either AAs (P for trend = 0. 62) or CAs (P for trend = 0.42). In contrast to a recent report on a select population that has less complete information on CaP aggressiveness suggesting that coffee prevents aggressive CaP, this rapid case ascertainment population-based study, in a biracial population with differing risks of CaP did not demonstrate a protective relationship between high coffee consumption and risk of high aggressive CaP.
本研究利用北卡罗来纳州-路易斯安那州前列腺癌项目（PCaP）中一项基于人群的前列腺癌研究的数据，评估了含咖啡因和脱咖啡因咖啡与前列腺癌（CaP）侵袭性之间的关系。在诊断时，CaP 侵袭性的分类是基于 1049 名非裔美国人和 1083 名白种美籍研究对象的临床标准。咖啡的摄入量是通过改良的 NCI 饮食史问卷来衡量的。在饮用含咖啡因或脱咖啡因咖啡的人群中，CaP 侵袭性与咖啡摄入量之间没有显著关联。与不喝咖啡的人相比，每天饮用超过 4 杯咖啡的人患高度侵袭性 CaP 的 OR 为 0.92（95%CI=0.61, 1.39）。按种族分层的结果发现，无论在非裔美国人（P 趋势=0.62）还是白种美籍人中（P 趋势=0.42），都没有显著关联，也没有明显的趋势。与最近一项针对特定人群的研究报告相反，该报告对 CaP 侵袭性的信息不够完整，表明咖啡可以预防侵袭性 CaP，这项快速病例发现的基于人群的研究，在具有不同 CaP 风险的双种族人群中，并未显示高咖啡摄入量与高侵袭性 CaP 风险之间存在保护关系。
