Balasubramanian K, Sivashanmugam P, Thameemdheen S, Govindarajulu P
Department of Endocrinology, University of Madras, India.
Indian J Exp Biol. 1991 Oct;29(10):907-9.
Diabetes mellitus caused significant reduction in serum testosterone and accessory sex glands weight. The sperm content of epididymal regions also decreased. Among the epididymal regions, the cauda epididymidal tissue alone showed significant reduction in Na(+)-K+ ATPase activity. However, Mg2+ ATPase activity was lowered in caput epididymidis only. Specific activity of Ca2+ ATPase significantly decreased in caput and cauda epididymides. All three ATPases decreased significantly in caput epididymidal spermatozoa leaving cauda epididymidal spermatozoa unaffected. Specific activity of alkaline phosphatase was suppressed in caput epididymidis and in the spermatozoa collected from caput and cauda epididymides, while the acid phosphatase was unaffected. In general, the results are suggestive of definite influence of diabetes on epididymal phosphatases which is region specific. Diabetes induced decrease in phosphatases may have an impact on secretory and absorptive functions of epididymis and thus on sperm maturation.
糖尿病导致血清睾酮和附属性腺重量显著降低。附睾区域的精子含量也减少。在附睾各区域中，仅附睾尾部组织的Na(+)-K+ ATP酶活性显著降低。然而，仅附睾头部的Mg2+ ATP酶活性降低。附睾头部和尾部的Ca2+ ATP酶比活性显著降低。附睾头部精子的所有三种ATP酶均显著降低，而附睾尾部精子未受影响。附睾头部的碱性磷酸酶比活性以及从附睾头部和尾部收集的精子中的碱性磷酸酶比活性均受到抑制，而酸性磷酸酶未受影响。总体而言，结果表明糖尿病对附睾磷酸酶有明确影响，且具有区域特异性。糖尿病诱导的磷酸酶降低可能会影响附睾的分泌和吸收功能，进而影响精子成熟。
