Vanithakumari G, Govindarajulu P
Indian J Physiol Pharmacol. 1985 Jan-Mar;29(1):1-6.
Studies on the distribution of Na+, K+-dependent, Mg2+ dependent and Ca2+ dependent Adenosine Triphosphatase (ATP-ases) in the testes, epididymis, seminal vesicles and prostate glands of mature bonnet monkeys were carried out with and without Testosterone propionate (TP) treatment. Comparatively, the Ca2+ dependent ATP-ase was very active in the testes, caput and cauda epididymis and prostate of control animals. However, the Mg2+-dependent ATP-ase activity was predominant in the seminal vesicles. In all the genital tissues the Na+, K+ dependent ATP-ase exhibited low activity compared to other ATP-ase systems. On TP treatment at 1 mg/kg body wt. dose for 30 consecutive days to the second group of animals, all classes of ATP-ases drastically decreased in the testes, cauda epididymis, seminal vesicles and prostate. While in caput epididymis the Mg2+-dependent ATP-ase was stimulated, the Na+, K+-dependent ATP-ase was decreased both in the caput and corpus epididymis by the hormone treatment. The present study reveals the general inhibitory influence on the ATP-ase systems and thereby ionic transport after long term TP administration.
对成年冠毛猕猴的睾丸、附睾、精囊和前列腺中钠钾依赖性、镁依赖性和钙依赖性三磷酸腺苷酶（ATP酶）的分布进行了研究，研究分为给予和不给予丙酸睾酮（TP）处理两组。相对而言，钙依赖性ATP酶在对照组动物的睾丸、附睾头和尾以及前列腺中活性很高。然而，镁依赖性ATP酶活性在精囊中占主导地位。在所有生殖组织中，钠钾依赖性ATP酶与其他ATP酶系统相比活性较低。对第二组动物连续30天以1mg/kg体重的剂量给予TP处理后，睾丸、附睾尾、精囊和前列腺中所有类型的ATP酶均大幅下降。而在附睾头中，镁依赖性ATP酶受到刺激，激素处理使附睾头和体中的钠钾依赖性ATP酶均减少。本研究揭示了长期给予TP后对ATP酶系统以及由此对离子转运的总体抑制作用。
