Oszajca Katarzyna, Szemraj Janusz, Bartkowiak Jacek
Department of Medical Biochemistry, Medical University of Lodz, 6/8 Mazowiecka St., 92-215 Lódź, Poland.
Postepy Biochem. 2005;51(4):407-13.
Nitric oxide produced in various human tissues by nitric oxide synthase is involved in the regulation of many physiological processes. Mechanism of its action is diverse. The most important physiological activity of nitric oxide is guanylate cyclase activation and an increase of cGMP synthesis. At low concentrations NO plays a pivotal role in vessel relaxation and possesses antithrombotic, antiproliferative and anti-inflammatory features as well. An excessive production of nitric oxide can disturb vascular hemostasis and contribute to development of cardiovascular diseases. Studies provide that NO also participate in fibrynolysis regulation by the influence on the PAI-1 and t-PA expression, what may have important clinical implications. The aim of this review is to present current knowledge about the role of nitric oxide in the regulation of these plasminogen activation system factors.
一氧化氮合酶在人体各种组织中产生的一氧化氮参与多种生理过程的调节。其作用机制多种多样。一氧化氮最重要的生理活性是激活鸟苷酸环化酶并增加环磷酸鸟苷（cGMP）的合成。在低浓度时，一氧化氮在血管舒张中起关键作用，还具有抗血栓形成、抗增殖和抗炎特性。一氧化氮的过量产生会扰乱血管止血并促进心血管疾病的发展。研究表明，一氧化氮还通过影响纤溶酶原激活物抑制剂-1（PAI-1）和组织型纤溶酶原激活物（t-PA）的表达参与纤维蛋白溶解调节，这可能具有重要的临床意义。本综述的目的是介绍关于一氧化氮在调节这些纤溶酶原激活系统因子中作用的当前知识。
