Willerson J T, Parkey R W, Bonte F J, Meyer S L, Stokely E M
Circulation. 1975 Mar;51(3):436-41. doi: 10.1161/01.cir.51.3.436.
Eighty-eight patients admitted to a coronary care unit with chest pain of varying etiology but without ECG evidence of an acute transmural myocardial infarction had myocardial scintigrams using technetium-99m stannour pyrophosphate (99m-Tc-PYP). Seventeen of these patients had ECG and enzymatic evidence suggestive of acute subendocardial myocardial infarction. In each of these the scintigrams were postivie demonstrating increased 99m-Tc-PYP uptake either in a faintly but diffusely positive pattern or in a well-localized strongly positive one. The remaining 71 patients did not evolve ECG or enzymatic evidence of acute myocardial infarction. In each of these patients the myocardial scintigram was negative. Thus 99m-Tc-PYP myocardial scintigrams are capable of identifying the presence of acute subendocardial myocardial infarction in patients. The absolute frequency with shich subendocardial myocardial infarction can be recognized utilizing this technique will have to be established in a larger number of patients in the future.
88名因各种病因胸痛而入住冠心病监护病房但心电图无急性透壁性心肌梗死证据的患者，使用锝-99m焦磷酸亚锡（99m-Tc-PYP）进行了心肌闪烁扫描。其中17名患者有心电图和酶学证据提示急性心内膜下心肌梗死。在每例此类患者中，闪烁扫描均为阳性，显示99m-Tc-PYP摄取增加，呈轻度但弥漫性阳性模式或定位良好的强阳性模式。其余71名患者未出现急性心肌梗死的心电图或酶学证据。在每例此类患者中，心肌闪烁扫描均为阴性。因此，99m-Tc-PYP心肌闪烁扫描能够识别患者是否存在急性心内膜下心肌梗死。未来需要在更多患者中确定利用该技术能够识别心内膜下心肌梗死的绝对频率。
