Ahmad M, Dubiel J P, Logan K W, Verdon T A, Martin R H
Am J Cardiol. 1977 Jan;39(1):50-4. doi: 10.1016/s0002-9149(77)80010-6.
To test the sensitivity and specificity of technetium-99m stannous pyrophosphate myocardial imaging in the diagnosis of acute myocardial infarction, myocardial scintigrams were performed in 115 patients. Positive scintigrams were found in all 48 patients with acute myocardial infarction; uptake was localized in 29 patients with transmural infarction and diffuse in 2 patients with transmural infarction and in the remaining 17 patients with subendocardial myocardial infarction. Positive scintigrams were also found in 31 of 67 patients without clinical evidence of acute myocardial infarction. Diffusely positive scintigrams were found in 3 of 3 patients with unstable angina pectoris, 7 of 30 patients with stable angina pectoris, 4 of 13 patients who had undergone aortocoronary bypass surgery, 4 of 4 patients with congestive cardiomyopathy and 1 patient studied 1 day after direct current cardioversion. Localized uptake of 99mTc-pyrophosphate was found in 9 of 10 patients with left ventricular aneurysm and in 3 of 13 patients after aortocoronary bypass surgery. All four patients with atypical chest pain and two patients with pericarditis had normal scintigrams. Our data confirm the previously reported sensitivity of 99mTc-pyrophosphate imaging in detection of acute myocardial infarction but indicate that positive scintigrams are not specific for this entity.
为检测锝-99m焦磷酸亚锡心肌显像在急性心肌梗死诊断中的敏感性和特异性，对115例患者进行了心肌闪烁扫描。48例急性心肌梗死患者的扫描结果均为阳性；29例透壁性梗死患者的摄取呈局限性，2例透壁性梗死患者和其余17例心内膜下心肌梗死患者的摄取呈弥漫性。67例无急性心肌梗死临床证据的患者中，31例扫描结果也为阳性。不稳定型心绞痛3例患者中3例扫描结果呈弥漫性阳性，稳定型心绞痛30例患者中7例阳性，接受主动脉冠状动脉搭桥手术的13例患者中4例阳性，充血性心肌病4例患者中4例阳性，1例在直流电复律后1天接受检查的患者阳性。左心室室壁瘤10例患者中9例和主动脉冠状动脉搭桥手术后13例患者中3例发现99mTc-焦磷酸的局限性摄取。4例非典型胸痛患者和2例心包炎患者的扫描结果均正常。我们的数据证实了先前报道的99mTc-焦磷酸显像在检测急性心肌梗死方面的敏感性，但表明阳性扫描结果对该疾病并不具有特异性。
