Teixeira A R, Lacava Z, Santana J M, Luna H
Departamento de Patologia, Faculdade de Ciências da Saúde, Universidade de Brasilia, DF.
Rev Soc Bras Med Trop. 1991 Jan-Mar;24(1):55-8. doi: 10.1590/s0037-86821991000100010.
Trypanosoma cruzi chromatin was observed in macrophage chromosome spreads obtained at different periods of infections in BALB/c mice. Immunofluorescent studies showed that genetic materials associated with the chromosomes were T. cruzi products. In situ hybridization showed the protozoon DNA insertion in the host cell genome. In addition, selective 3H-DNA insertion in chromosomes 3, 6 and 11 was observed, which suggested that transxenogene rearrangement may take place in T. cruzi infections of mammals.
