Leachman Sancy A, Reed Barbara R
Tom C. Mathews Jr. Familial Melanoma Research Clinic, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Suite 5242, Salt Lake City, UT 84112, USA.
Dermatol Clin. 2006 Apr;24(2):167-97, vi. doi: 10.1016/j.det.2006.01.001.
Physicians are generally reluctant to prescribe dermatologic drugs to pregnant or nursing women because treatment is often elective and can be harmful to the patient, her fetus, or nursing infant; concerns for potential litigation also give pause. Yet, some effective dermatologic drugs have been determined to be safe during pregnancy and lactation. Of great practicality is an easily accessed reference guide that condenses information on such drugs into a set of tables that list pregnancy and teratogenicity ratings. Indications and contraindications are ordered in relation to the phases and trimesters of pregnancy. A discussion of the necessity of considering stages of childbearing in choosing drug therapies introduces the tables. A summary list of cautions spells out the steps physicians should take in treating women of childbearing age.
医生通常不愿意给孕妇或哺乳期妇女开皮肤科药物，因为治疗往往是选择性的，而且可能对患者、其胎儿或哺乳期婴儿有害；对潜在诉讼的担忧也让人犹豫不决。然而，一些有效的皮肤科药物已被确定在妊娠和哺乳期是安全的。一个非常实用的方法是有一本易于获取的参考指南，将此类药物的信息浓缩成一组列出妊娠和致畸性评级的表格。适应症和禁忌症是按照妊娠阶段和孕期来排列的。在选择药物治疗时考虑生育阶段的必要性的讨论引入了这些表格。一份注意事项总结清单详细说明了医生在治疗育龄妇女时应采取的步骤。
