Zesch A
Institut für Arzneimittel des Bundesgesundheitsamtes Berlin.
Hautarzt. 1990 Jul;41(7):365-8.
Any instance of drug administration during pregnancy can pose problems and will always take place after careful consideration and specific benefit risk evaluation. Even in the case of local therapy, which is rightly considered particularly safe, several active substances are applied whose embryotoxic potential is either relevant when given systemically in animals or humans, or unknown. With this in mind, several active substances designed for topical application are discussed that should not be applied at all during pregnancy or only within defined periods, even under various conditions of local therapy. The borderlines are unclear, and are indicated with particular reference to areas for which no reliable data are available.
孕期任何药物给药情况都可能带来问题，并且总是要在经过仔细考虑和具体的效益风险评估后才会进行。即使是被认为特别安全的局部治疗，也会使用几种活性物质，这些物质的胚胎毒性潜力在动物或人类全身给药时要么相关，要么未知。考虑到这一点，讨论了几种设计用于局部应用的活性物质，即使在各种局部治疗条件下，在孕期也根本不应使用或仅在规定时期内使用。界限并不明确，特别是在没有可靠数据的领域给出了指示。
