鞭毛内运输与基于纤毛的信号传导。

Intraflagellar transport and cilium-based signaling.

作者信息

Scholey Jonathan M, Anderson Kathryn V

机构信息

Center for Genetics and Development, Section of Molecular and Cell Biology, University of California, Davis, CA 95616, USA.

出版信息

Cell. 2006 May 5;125(3):439-42. doi: 10.1016/j.cell.2006.04.013.

DOI:10.1016/j.cell.2006.04.013

PMID:16678091

Abstract

Cilia are specialized structures that not only play diverse roles in cell motility but also transmit signals to the cytoplasm and nucleus to control gene expression, cell function, animal development, and behavior. Cilia are assembled and maintained by the intraflagellar transport (IFT) machinery, which coordinates rapid, bidirectional transport between the cell body and the distal tip of the cilium. A new study (Wang et al., 2006) illuminates the role of IFT in cilium-based signaling during mating in the alga Chlamydomonas.

摘要

纤毛是一种特殊结构，不仅在细胞运动中发挥多种作用，还能将信号传递到细胞质和细胞核，以控制基因表达、细胞功能、动物发育和行为。纤毛由鞭毛内运输（IFT）机制组装和维持，该机制协调细胞体与纤毛远端之间的快速双向运输。一项新的研究（Wang等人，2006年）阐明了IFT在藻类衣藻交配过程中基于纤毛的信号传导中的作用。