Zhao Gang, Zhang Hai-Feng, Guo Xiao-Jie, Luo Da-Wei, Gao Da-Yong
Department of Thermal Science and Energy Engineering, University of Science and Technology of China, Hefei 230027, PR China.
Med Eng Phys. 2007 Mar;29(2):205-15. doi: 10.1016/j.medengphy.2006.03.005. Epub 2006 May 6.
Cryosurgery has been recently accepted as a treatment option for eradicating undesirable tissues, especially tumor tissues, due to its minimally invasive nature and low hospitalization needs. A multidimensional, finite element analysis (FEA) for the cooling, holding and rewarming processes of biological tissues during cryosurgery is presented. The tissues were treated as non-ideal materials with temperature dependent thermophysical properties. The enthalpy method has been applied to solve the non-linear problem. The influence of heating effect due to blood flow and metabolism was studied, and furthermore, the effect of pre-injecting solutions with particular thermal properties into the target tissues was also numerically studied. It was found that the heat source term due to blood flow and metabolism in the bioheat transfer equation has a significant influence on the thermal and thermal gradient histories of the target tissues, and that the method of injection of solutions with particular thermal properties into the target tissues before cryosurgery may be a possible way to optimize the treatment process. However, in vitro experiments have not fully supported this viewpoint.
由于其微创性和低住院需求，冷冻手术最近已被视为一种根除不良组织，尤其是肿瘤组织的治疗选择。本文提出了一种用于冷冻手术期间生物组织冷却、保持和复温过程的多维有限元分析（FEA）。组织被视为具有温度依赖性热物理性质的非理想材料。采用焓法求解非线性问题。研究了血流和代谢引起的加热效应的影响，此外，还对向靶组织预注射具有特定热性质的溶液的效果进行了数值研究。结果发现，生物传热方程中由于血流和代谢引起的热源项对靶组织的热历史和热梯度历史有显著影响，并且在冷冻手术前向靶组织注射具有特定热性质的溶液的方法可能是优化治疗过程的一种可行方法。然而，体外实验尚未完全支持这一观点。
