Porteous David J, Millar J Kirsty
Medical Genetics Section, Edinburgh University Centre for Molecular Medicine, Western General Hospital Campus, Crewe Road, Edinburgh EH4 2XU, UK.
Trends Mol Med. 2006 Jun;12(6):255-61. doi: 10.1016/j.molmed.2006.04.009. Epub 2006 May 6.
Schizophrenia and bipolar affective disorder are common, debilitating, and poorly understood and treated disorders. Both conditions are highly heritable. Recent genetic studies have suggested that the gene disrupted in schizophrenia 1 (DISC1) is an important risk factor. DISC1 seems to have a key role in building the brain and memories by interacting with other proteins, including nuclear distribution E-like protein and phosphodiesterase 4B. Here, we review the current knowledge, highlight some key unanswered questions and propose ways forward towards a better understanding of normal and abnormal brain development and function. In the long term, this might lead to the discovery of drugs that are more efficacious and safer than currently available ones.
精神分裂症和双相情感障碍是常见、使人衰弱且了解和治疗不足的疾病。这两种病症都具有高度遗传性。近期的基因研究表明，精神分裂症1号基因（DISC1）是一个重要的风险因素。DISC1似乎通过与其他蛋白质相互作用，包括核分布E样蛋白和磷酸二酯酶4B，在构建大脑和记忆方面发挥关键作用。在此，我们回顾当前的知识，突出一些关键的未解决问题，并提出进一步深入理解正常和异常大脑发育及功能的方法。从长远来看，这可能会促成比现有药物更有效、更安全的药物的发现。
