Institute of Health and Biomedical Innovation at the Queensland Centre for Children's Health Research, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
School of Exercise and Nutrition Science, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
BMC Pediatr. 2021 Mar 1;21(1):105. doi: 10.1186/s12887-021-02566-7.
Posterior fossa brain tumors (PFBT) are the most common solid tumor in children. Recent increases in survival rates are encouraging; however, survivors may experience a plethora of disease- and treatment-related complications that can persist into adulthood. Therapeutic exercise interventions have been shown to improve quality of survivorship in other pediatric cancer diagnoses. There is also evidence that goal-directed interventions are effective at improving motor activities, function, and self-care in children with complex health conditions. Yet, there is currently no evidence on the efficacy of goal-directed therapeutic exercise in pediatric PFBT survivors. The Physical ACTivity in Survivorship (PACTS) study aims to investigate the effects of a novel goal-directed therapeutic exercise program on cardiorespiratory fitness and physical activity-related goal attainment in pediatric survivors of PFBT.
PFBT survivors, aged five to 17 years, who underwent surgery at least 12 months earlier and completed radiation therapy and/or chemotherapy at least 6 months prior will be recruited from the Queensland Children's Hospital (Brisbane, Australia) (target n = 48). Following baseline assessment, participants are randomized into either the intervention or usual care group. The intervention group will receive weekly individualized, goal-directed exercise therapy delivered face-to-face for 12 weeks, along with an accompanying home-based program (three sessions per week). Outcomes will be assessed at baseline, immediately post-intervention, and at 6- and 12-months post-intervention. The primary outcomes are cardiorespiratory fitness (Peak VO) and physical activity-related goal attainment. Secondary outcomes are cardiorespiratory endurance, high-level mobility skills, functional muscle strength, habitual physical activity, gait, balance, quality of life, fatigue, participation, perceived movement skill competence and parameters of body composition.
PACTS is the first study to investigate the efficacy of goal-directed therapeutic exercise in children with PFBT and provide evidence needed to inform clinical practice recommendations for managing quality of survivorship in PFBT survivors.
ACTRN12619000841178 .
后颅窝脑肿瘤（PFBT）是儿童最常见的实体瘤。最近存活率的提高令人鼓舞；然而，幸存者可能会经历大量与疾病和治疗相关的并发症，这些并发症可能会持续到成年期。治疗性运动干预已被证明可提高其他儿科癌症诊断的生存质量。有证据表明，目标导向干预措施可有效改善患有复杂健康状况的儿童的运动活动、功能和自我护理。然而，目前尚无关于目标导向治疗性运动对儿科 PFBT 幸存者疗效的证据。身体活动在生存中的作用（PACTS）研究旨在调查一种新的目标导向治疗性运动方案对 PFBT 后儿童心肺适能和与身体活动相关目标实现的影响。
将至少在 12 个月前接受过手术且至少在 6 个月前完成过放化疗的 5 至 17 岁 PFBT 幸存者从昆士兰儿童医院（澳大利亚布里斯班）招募（目标人数 n=48）。在基线评估后，参与者被随机分配到干预组或常规护理组。干预组将接受每周一次的个体化、目标导向的运动治疗，持续 12 周，并同时进行家庭基础计划（每周三次）。结果将在基线、干预后即刻以及干预后 6 个月和 12 个月进行评估。主要结果是心肺适能（峰值 VO）和与身体活动相关的目标实现。次要结果是心肺耐力、高水平移动技能、功能性肌肉力量、习惯性身体活动、步态、平衡、生活质量、疲劳、参与度、运动技能感知能力和身体成分参数。
PACTS 是第一项研究治疗性运动对 PFBT 儿童的疗效的研究，并提供了为管理 PFBT 幸存者生存质量提供循证医学实践建议所需的证据。
ACTRN12619000841178。
