胃饥饿素——葡萄糖稳态中的新角色？

Ghrelin--a new player in glucose homeostasis?

作者信息

Ahima Rexford S

机构信息

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

出版信息

Cell Metab. 2006 May;3(5):301-2. doi: 10.1016/j.cmet.2006.04.006.

DOI:10.1016/j.cmet.2006.04.006

PMID:16679286

Abstract

The hormone ghrelin regulates secretion of growth hormone and energy homeostasis. Sun et al (2006), in this issue of Cell Metabolism, demonstrate that ghrelin inhibits insulin secretion. Deletion of ghrelin increased basal insulin level, enhanced glucose-stimulated insulin secretion, and improved peripheral insulin sensitivity. These effects were not related to changes in food intake or weight, suggesting ghrelin has unique actions on key components of glucose homeostasis.

摘要

胃饥饿素这种激素调节生长激素的分泌和能量平衡。孙等人（2006年）在本期《细胞代谢》中表明，胃饥饿素会抑制胰岛素分泌。胃饥饿素缺失会增加基础胰岛素水平，增强葡萄糖刺激的胰岛素分泌，并改善外周胰岛素敏感性。这些作用与食物摄入量或体重的变化无关，这表明胃饥饿素对葡萄糖稳态的关键组成部分具有独特作用。