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鼓室内注射类固醇作为突发性听力损失的挽救疗法:初步结果

Transtympanic steroids as a salvage therapy in sudden hearing loss: preliminary results.

作者信息

Dallan Iacopo, Bruschini Luca, Nacci Andrea, Bruschini Paolo, Traino Claudio, Rognini Ferdinando, Fattori Bruno

机构信息

Second ENT Unit, Pisa University Hospital, Pisa, Italy.

出版信息

ORL J Otorhinolaryngol Relat Spec. 2006;68(5):247-52. doi: 10.1159/000093093. Epub 2006 May 4.

Abstract

PURPOSE

To understand the real efficacy of transtympanic steroid therapy for sudden sensorineural hearing loss (SSHL) in patients in whom traditional therapies have failed.

PROCEDURES

A prospective study was designed in order to evaluate hearing improvement in SSHL patients treated with transtympanic therapy. A solution of methyl-prednisolone (MP) and sodium bicarbonate was administered via a transtympanic injection to 8 patients. Hearing level was evaluated before therapy and at days 1, 7 and 30.

RESULTS

Hearing improvement was obtained in 75% of the patients. The patients in this category are usually considered untreatable.

CONCLUSION

Transtympanic steroid therapy is an efficacious solution for patients affected by SSHL in whom traditional therapies have failed. Further studies will be required to identify the most favourable dosage, route of administration and type of steroid. Transtympanic steroid application is safe, inexpensive, easy to perform and efficacious in cases of SSHL not responsive to traditional therapy.

摘要

目的

了解经鼓膜类固醇疗法对传统疗法治疗失败的突发性感音神经性听力损失(SSHL)患者的实际疗效。

程序

设计了一项前瞻性研究,以评估接受经鼓膜疗法治疗的SSHL患者的听力改善情况。通过经鼓膜注射向8例患者给予甲基强的松龙(MP)和碳酸氢钠溶液。在治疗前以及治疗后第1、7和30天评估听力水平。

结果

75%的患者听力得到改善。这类患者通常被认为无法治疗。

结论

经鼓膜类固醇疗法对于传统疗法治疗失败的SSHL患者是一种有效的治疗方法。需要进一步研究以确定最有利的剂量、给药途径和类固醇类型。经鼓膜应用类固醇是安全、廉价、易于实施的,并且对传统治疗无反应的SSHL病例有效。

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