Medical Residency Program in Otorhinolaryngology and Head & Neck Surgery, Brasilia University Hospital, University of Brasilia, Brazil.
Braz J Otorhinolaryngol. 2010 Jul-Aug;76(4):499-509. doi: 10.1590/S1808-86942010000400015.
Treatment in sudden sensorineural hearing loss is a contentious issue, today, oral steroids are the most common choice and considered the best treatment option, but the use of intratympanic steroids has become an attractive alternative, especially in cases when systemic therapy fails, or to avoid the side effects of the systemic use of steroids.
To describe the results of intratympanic methylprednisolone in idiopathic sudden sensorineural hearing loss after failure of oral prednisolone.
In a prospective study fourteen patients with idiopathic sudden sensorineural hearing loss were treated with intratympanic methylprednisolone after failing in the treatment with systemic steroids. Pretreatment and post-treatment audiometric evaluations including pure tone average (PTA) and speech reception thresholds (SRT) were analyzed.
Ten from 14 patients treated with intra-tympanic methylprednisolone presented with hearing recovery > 20 dB in PTA or 20% in SRT.
Three intratympanic injections of methylprednisolone improved pure-tone average or speech discrimination scores for a subset of sudden hearing loss subjects that failed to benefit from oral steroids.
突发性聋的治疗是一个有争议的问题，目前，口服类固醇是最常见的选择，被认为是最佳治疗方案，但鼓室内类固醇的使用已成为一种有吸引力的替代方案，特别是在全身治疗失败的情况下，或为了避免全身使用类固醇的副作用。
描述口服泼尼松龙治疗失败后鼓室内甲泼尼龙治疗特发性突发性聋的结果。
在一项前瞻性研究中，14 例特发性突发性聋患者在全身类固醇治疗失败后接受鼓室内甲泼尼龙治疗。对纯音平均（PTA）和言语接受阈（SRT）进行预处理和后处理听力评估。
14 例接受鼓室内甲泼尼龙治疗的患者中，10 例患者 PTA 听力恢复>20dB 或 SRT 提高 20%。
3 次鼓室内注射甲泼尼龙可改善一组未能从口服类固醇中获益的突发性聋患者的纯音平均或言语辨别评分。
Zotero 插件
