Ermutlu Gülce, Süslü Nilda, Yılmaz Taner, Saraç Sarp
Department of Otorhinolaryngology and Head and Neck Surgery, Hacettepe University, Ankara, Turkey.
Kağıthane Devlet Hastanesi, Sanayi Mahallesi Sultan Selim Caddesi, Şahinler Sokak No:23 Kağıthane, İstanbul, Turkey.
Eur Arch Otorhinolaryngol. 2017 Oct;274(10):3585-3591. doi: 10.1007/s00405-017-4691-8. Epub 2017 Jul 29.
Corticosteroid treatment has been considered the most effective treatment modality for sudden sensorineural hearing loss so far. Application route of corticosteroids may vary. We have designed a prospective randomized case-controlled clinical trial to evaluate the effectivenesses of the different application routes of steroids in the treatment of SSHL. Thirty-five patients were distributed randomly to two groups which were treated with either 'oral' or 'intratympanic' corticosteroids. Intratympanic steroid administration was performed three times every other day transtympanically. At the end of third month, recovery rate in the 'intratympanic' group was 84.2%, whereas in the 'oral' group, it was 87.5%. The difference between the recovery rates was not statistically significant. There were no major complications related to transtympanic steroid administration. These findings support that intratympanic steroid therapy is an alternative to systemic steroid therapy in the initial treatment of sudden hearing loss. In addition, transtympanic technique is an easy to perform and safe method for delivering steroids into the inner ear.
迄今为止，皮质类固醇治疗一直被认为是突发性感音神经性听力损失最有效的治疗方式。皮质类固醇的应用途径可能有所不同。我们设计了一项前瞻性随机病例对照临床试验，以评估类固醇不同应用途径在治疗突发性感音神经性听力损失中的有效性。35例患者被随机分为两组，分别接受“口服”或“鼓室内”皮质类固醇治疗。鼓室内类固醇给药每隔一天经鼓膜进行3次。在第三个月末，“鼓室内”组的恢复率为84.2%，而“口服”组为87.5%。恢复率之间的差异无统计学意义。鼓室内类固醇给药未出现重大并发症。这些发现支持鼓室内类固醇治疗在突发性听力损失的初始治疗中是全身类固醇治疗的一种替代方法。此外，经鼓膜技术是一种将类固醇输送到内耳的易于实施且安全的方法。
