Krishnani N, Agarwal A, Singh M
Department of Pathology, G.S.V.M. Medical College, Kanpur.
Indian J Pathol Microbiol. 1991 Jul;34(3):166-71.
The association of Human Papilloma Virus (HPV) with cervical lesions was correlated using peroxidase anti-peroxidase (PAP) technique and in-situ molecular hybridization (MH) with H3 labelled DNA probes (HPV type 6, 11, 16 and 18). The PAP technique to demonstrate capsid antigen and molecular hybridization for DNA sequences was studied in 30 cases. The correlation of HPV with cervical lesions was seen in 29.9% cases with PAP technique unlike 73.4% using M.H. technique, indicating the efficacy of the latter.
采用过氧化物酶抗过氧化物酶（PAP）技术以及使用H3标记的DNA探针（6、11、16和18型人乳头瘤病毒）的原位分子杂交（MH）技术，对人乳头瘤病毒（HPV）与宫颈病变的关联进行了研究。对30例病例进行了用于显示衣壳抗原的PAP技术和用于DNA序列的分子杂交研究。使用PAP技术时，HPV与宫颈病变的关联在29.9%的病例中可见，而使用MH技术时这一比例为73.4%，表明后者的有效性。
