Matsumoto M
Department of Neurosurgery, Kyoto University Medical School, Japan.
Nihon Geka Hokan. 1991 Mar 1;60(2):113-21.
Recent reports suggest that protein phosphorylation is involved in neural differentiation. We have found that specific inhibitors of protein phosphorylation at tyrosine residues, Erbstatin, Genistein, Herbimycin A, effectively induce neural differentiation in a human neuroblastoma cell line SK-N-DZ and a human medulloblastoma cell line Med-3, as indicated by the marked increase in the number of neurites/cell and in the expression of neurofilaments (160 k) detected by immunohistochemical studies. Possible involvement of protein phosphorylation at tyrosine residues in the differentiation of neural tumor cells was stressed.
最近的报告表明蛋白质磷酸化参与神经分化过程。我们发现，酪氨酸残基蛋白磷酸化的特异性抑制剂埃博他汀、染料木黄酮、赫曲霉素A，可有效诱导人神经母细胞瘤细胞系SK-N-DZ和人髓母细胞瘤细胞系Med-3发生神经分化，免疫组织化学研究检测显示，神经突/细胞数量显著增加以及神经丝（160k）表达显著增加就表明了这一点。强调了酪氨酸残基蛋白磷酸化可能参与神经肿瘤细胞的分化。
