Steinert Tilman, Kallert Thomas W
Psychiatrische Versorgungsforschung am Zentrum für Psychiatrie, Die Weissenau, Abt. Psychiatrie I der Universität Ulm.
Psychiatr Prax. 2006 May;33(4):160-9. doi: 10.1055/s-2005-867054.
A systematic review should take into account epidemiological, clinical, ethical, and legal aspects.
Search for literature was performed by Medline and Medpilot, guidelines were obtained via the internet or from own ongoing research projects.
Epidemiological data on the frequency of involuntary medication is only scarcely available. The incidence on psychiatric wards seems to be between 2 % and 8 % of patients, predominantly with schizophrenic or bipolar disorder. In general, the efficacy of involuntary medication has been poorly evaluated in inpatients, two randomised controlled trials from the U. S. are available regarding involuntary outpatient commitment including involuntary medication. Therefore, the empirical database on aspects of clinical safety of involuntary medication is quite small. However, a considerable body of literature exists with respect to patients' opinions on involuntary medication, mostly demonstrating a highly critical attitude. Some European countries already have guidelines, but the overall situation suggests the need for further improvement. In 2004, the EU Council ratified a guideline for future European legislation on involuntary treatment of people with serious mental illness (white paper).
A very controversial discussion of former years has become more reasonable, ideological anti-psychiatric criticism being increasingly replaced by search for evidence, development of guidelines, clearer legislation, and a tendency of European harmonization.
系统评价应考虑流行病学、临床、伦理和法律等方面。
通过医学文献数据库(Medline)和医学导航(Medpilot)检索文献,指南通过互联网或自身正在进行的研究项目获取。
关于非自愿用药频率的流行病学数据非常稀少。精神科病房的发生率似乎在患者的2%至8%之间,主要是患有精神分裂症或双相情感障碍的患者。总体而言,住院患者中非自愿用药的疗效评估不佳,美国有两项关于非自愿门诊治疗(包括非自愿用药)的随机对照试验。因此,关于非自愿用药临床安全性方面的实证数据库相当小。然而,关于患者对非自愿用药看法的文献相当多,大多表明持高度批评态度。一些欧洲国家已经有了指南,但总体情况表明仍有进一步改进的必要。2004年,欧盟理事会批准了一项关于未来欧洲对严重精神疾病患者非自愿治疗立法的指南(白皮书)。
过去多年来一场极具争议的讨论变得更加合理,意识形态上的反精神病学批评日益被寻求证据、制定指南、更清晰的立法以及欧洲协调的趋势所取代。