Cenquizca Lee A, Swanson Larry W
Department of Life Sciences, Los Angeles City College, Los Angeles, California 90029, USA.
J Comp Neurol. 2006 Jul 1;497(1):101-14. doi: 10.1002/cne.20985.
The hippocampal formation is generally considered essential for processing episodic memory. However, the structural organization of hippocampal afferent and efferent axonal connections is still not completely understood, although such information is critical to support functional hypotheses. The full extent of axonal projections from field CA1 to the interbrain (diencephalon) is analyzed here with the Phaseolus vulgaris-leucoagglutinin (PHAL) method. The ventral pole of field CA1 establishes direct pathways to, and terminal fields within, the anterior hypothalamic nucleus, ventromedial hypothalamic nucleus, lateral hypothalamic and lateral preoptic areas, medial preoptic area, and certain other hypothalamic regions, as well as particular midline thalamic nuclei. These results suggest that hippocampal field CA1 modulates motivated or goal-directed behaviors, and physiological responses, associated with the targeted hypothalamic neuron populations.
海马结构通常被认为是处理情景记忆所必需的。然而，尽管此类信息对于支持功能假说至关重要，但海马传入和传出轴突连接的结构组织仍未被完全理解。在此，我们使用菜豆白细胞凝集素（PHAL）方法分析了从CA1区到间脑的轴突投射范围。CA1区的腹侧极与下丘脑前核、腹内侧下丘脑核、外侧下丘脑和外侧视前区、内侧视前区以及其他特定下丘脑区域以及某些中线丘脑核建立了直接通路并形成终末场。这些结果表明，海马CA1区调节与目标下丘脑神经元群体相关的动机性或目标导向行为以及生理反应。
