优化记忆表现和情绪状态：成年海马神经发生的多层次增强。
Optimizing memory performance and emotional states: multi-level enhancement of adult hippocampal neurogenesis.
机构信息
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: https://twitter.com/yadlee2.
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Curr Opin Neurobiol. 2023 Apr;79:102693. doi: 10.1016/j.conb.2023.102693. Epub 2023 Feb 21.
Adult hippocampal neurogenesis (AHN) plays a key role in modulating memory and emotion processing. A fundamental question remains on how to effectively modulate AHN to improve hippocampal function. Here, we review recent work on how distinct aspects of hippocampal neurogenesis, including the number, maturation state, and activity of adult-born neurons (ABNs), contribute to overall hippocampal function. We propose multi-level enhancement of hippocampal neurogenesis with the combination of increased number, elevated activity, and enhanced maturation of ABNs as a potential strategy to optimize overall hippocampal performance. In addition, integration of ABNs induces significant remodeling of the local hippocampal circuits, which may in turn modulates brain-wide network dynamics. We discuss recent progress on how integration of ABNs contributes to local hippocampal circuit and brain-wide network dynamics during behavior.
成人海马神经发生（AHN）在调节记忆和情绪处理方面起着关键作用。一个基本的问题仍然是如何有效地调节 AHN 以改善海马功能。在这里，我们回顾了最近关于海马神经发生的不同方面，包括新生神经元（ABN）的数量、成熟状态和活性，如何有助于整体海马功能的研究。我们提出了通过增加 ABN 的数量、提高其活性和促进其成熟来增强海马神经发生的多层次策略，作为优化整体海马表现的潜在策略。此外，ABN 的整合会引起局部海马回路的显著重塑，这反过来又可能调节大脑网络的动态。我们讨论了最近的进展，即 ABN 的整合如何有助于行为期间局部海马回路和大脑网络的动态。
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