Li Xiao-lu, Huang Yue-sheng, Peng Yi-zhi, Liao Zhen-jiang, Zhang Guo-an, Liu Qun, Tang Jin, Liu Xu-sheng, Luo Qi-zhi
Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, The Third Military Medical University, Chongqing 400038, PR China.
Zhonghua Shao Shang Za Zhi. 2006 Feb;22(1):15-8.
To investigate the clinical efficacy and safety of Acticoat (nanocrystalline silver dressing) for the treatment of residual burn wounds.
Ninety-eight patients with 166 residual burn wounds were enrolled in the multi-center randomized clinical trials. In addition to the routine treatment, Acticoat was applied onto the wounds of the trial group once a day if there was much exudation from the wound, or the dressing change was made every other two days when the wounds were clean. Silver sulfadiazine (SD-Ag) was used in the control group of patients. The healing time was observed up to 20 days. The healing rate on the 15th day after treatment was taken as the percentage of healing.
The average healing time was (12 +/- 5) days after the application of Acticoat, which was significantly shorter than that in control wounds with SD-Ag (16 +/- 6) days, (P = 0.005 < 0.01). The total effective rate of the wounds for trial was 97.05%, which was higher than that in control (94.17%) group, but there was no statistically significant difference. The bacterial clearing rate of the Acticoat group on the 6th and 12th post treatment day was 21.7% and 43.5% respectively, which was significantly higher than that in control group. No side-effect was observed in the two groups during the study.
Acticoat with nanocrystalline silver can promote the healing of residual burn wounds effectively.
探讨纳米银抗菌敷料（Acticoat）治疗烧伤残余创面的临床疗效及安全性。
采用多中心随机临床试验，选取98例患者的166处烧伤残余创面。试验组除常规治疗外，创面渗出较多时每日使用纳米银抗菌敷料，创面清洁时每2日换药1次；对照组使用磺胺嘧啶银（SD-Ag）。观察20天内创面愈合时间，以治疗后第15天的愈合率作为愈合百分比。
纳米银抗菌敷料组创面平均愈合时间为（12±5）天，显著短于磺胺嘧啶银对照组的（16±6）天，（P = 0.005 < 0.01）。试验组创面总有效率为97.05%，高于对照组的94.17%，但差异无统计学意义。纳米银抗菌敷料组治疗后第6天和第12天细菌清除率分别为21.7%和43.5%，显著高于对照组。研究期间两组均未观察到副作用。
纳米银抗菌敷料可有效促进烧伤残余创面愈合。
