Thomas L, Naumann P, Crea A
Immun Infekt. 1986 Nov;14(6):203-7.
The in vitro activity of ciprofloxacin and ofloxacin against 33 strains of mycobacteria was investigated in a comparative study. The resulting MIC values were compared with serum levels, measured in a cross-over study. Possible therapeutic application of these substances in mycobacterial infections are being discussed. We found the antimycobacterial activity of ciprofloxacin to be insufficient for its clinical application, whereas the corresponding MIC values for ofloxacin could be achieved in vivo. Further animal and clinical studies appear justified.
在一项比较研究中，对环丙沙星和氧氟沙星针对33株分枝杆菌的体外活性进行了研究。将所得的最低抑菌浓度（MIC）值与在交叉研究中测得的血清水平进行了比较。正在讨论这些物质在分枝杆菌感染中的可能治疗应用。我们发现环丙沙星的抗分枝杆菌活性不足以用于临床应用，而氧氟沙星相应的MIC值在体内可以达到。进一步的动物和临床研究似乎是合理的。
