Stoecklin Georg, Anderson Paul
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Adv Immunol. 2006;89:1-37. doi: 10.1016/S0065-2776(05)89001-7.
The inflammatory response is a complex physiologic process that requires the coordinate induction of cytokines, chemokines, angiogenic factors, effector-enzymes, and proteases. Although transcriptional activation is required to turn on the inflammatory response, recent studies have revealed that posttranscriptional mechanisms play an important role by determining the rate at which mRNAs encoding inflammatory effector proteins are translated and degraded. Most posttranscriptional control mechanisms function to dampen the expression of pro-inflammatory proteins to ensure that potentially injurious proteins are not overexpressed during an inflammatory response. Here we discuss the factors that regulate the stability and translation of mRNAs encoding pro-inflammatory proteins.
炎症反应是一个复杂的生理过程，需要细胞因子、趋化因子、血管生成因子、效应酶和蛋白酶的协同诱导。虽然转录激活是开启炎症反应所必需的，但最近的研究表明，转录后机制通过决定编码炎症效应蛋白的mRNA的翻译和降解速率发挥重要作用。大多数转录后控制机制的作用是抑制促炎蛋白的表达，以确保在炎症反应期间潜在有害的蛋白不会过度表达。在这里，我们讨论调节编码促炎蛋白的mRNA稳定性和翻译的因素。
