Feng Yiyuan, Zhu Sha, Liu Tengwen, Zhi Guoguo, Shao Bingjie, Liu Jibin, Li Baixue, Jiang Cen, Feng Quansheng, Wu Peijie, Wang Dong
School of Basic Medical Sciences and State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Pharmaceuticals (Basel). 2023 Aug 7;16(8):1114. doi: 10.3390/ph16081114.
RNA-binding proteins (RBPs), being pivotal elements in both physiological and pathological processes, possess the ability to directly impact RNA, thereby exerting a profound influence on cellular life. Furthermore, the dysregulation of RBPs not only induces alterations in the expression levels of genes associated with cancer but also impairs the occurrence of post-transcriptional regulatory mechanisms. Consequently, these circumstances can give rise to aberrations in cellular processes, ultimately resulting in alterations within the proteome. An aberrant proteome can disrupt the equilibrium between oncogenes and tumor suppressor genes, promoting cancer progression. Given their significant role in modulating gene expression and post-transcriptional regulation, directing therapeutic interventions towards RBPs represents a viable strategy for combating drug resistance in cancer treatment. RBPs possess significant potential as diagnostic and prognostic markers for diverse cancer types. Gaining comprehensive insights into the structure and functionality of RBPs, along with delving deeper into the molecular mechanisms underlying RBPs in tumor drug resistance, can enhance cancer treatment strategies and augment the prognostic outcomes for individuals afflicted with cancer.
RNA结合蛋白（RBPs）是生理和病理过程中的关键要素，具有直接影响RNA的能力，从而对细胞生命产生深远影响。此外，RBPs的失调不仅会导致与癌症相关基因的表达水平发生改变，还会损害转录后调控机制的发生。因此，这些情况会导致细胞过程出现异常，最终导致蛋白质组发生变化。异常的蛋白质组会破坏癌基因和肿瘤抑制基因之间的平衡，促进癌症进展。鉴于它们在调节基因表达和转录后调控中的重要作用，针对RBPs进行治疗干预是癌症治疗中对抗耐药性的可行策略。RBPs作为多种癌症类型的诊断和预后标志物具有巨大潜力。全面了解RBPs的结构和功能，以及深入探究RBPs在肿瘤耐药中的分子机制，可以改进癌症治疗策略，提高癌症患者的预后效果。
