Husmann Marc J, Barton Matthias, Amann-Vesti Beatrice R, Franzeck Ulrich K
Division of Angiology, University Hospital Zurich, Zurich, Switzerland.
J Vasc Res. 2006;43(4):321-6. doi: 10.1159/000093197. Epub 2006 May 8.
Direct assessment of the effect of postural changes on interstitial fluid pressure (IFP) in the human skin under physiological conditions is important for the understanding of mechanisms involved in diseases resulting in lower limb edema. Previous techniques to measure IFP had limitations of being invasive, and acute measurements were not possible. Here we describe the effect of postural changes on IFP in the skin of the foot using the minimally invasive servonulling technique.
Measurements were performed in 12 healthy subjects. IFP (means +/- SD) was significantly higher in the sitting (5.1 +/- 2.9 mm Hg) than in the supine position (-0.3 +/- 3.6 mm Hg, p = 0.04) when measured in the sitting position first. The difference between the sitting and the supine position was not significant when measurements were taken in the supine position first [from 1.0 +/- 4.3 (supine) to 3.6 +/- 6.7 mm Hg (sitting), p = 0.46]. Spontaneous low-frequency pressure fluctuations occurred in 58% of the recordings during sitting, which was almost twice as frequent as in the supine position (33%; p = 0.001), while no effects on lymphatic capillary network extension were observed (p = 0.12).
Using the servonulling micropressure system, postural effects on IFP can be directly assessed. IFP is higher in the sitting position, but differences are influenced by the time in the upright position.
在生理条件下直接评估姿势变化对人体皮肤间质液压力（IFP）的影响，对于理解导致下肢水肿的疾病所涉及的机制很重要。以往测量IFP的技术存在侵入性的局限性，且无法进行急性测量。在此，我们使用微创伺服归零技术描述姿势变化对足部皮肤IFP的影响。
对12名健康受试者进行了测量。当首先在坐位测量时，坐位的IFP（均值±标准差）显著高于仰卧位（5.1±2.9 mmHg对-0.3±3.6 mmHg，p = 0.04）。当首先在仰卧位测量时，坐位和仰卧位之间的差异不显著[从1.0±4.3（仰卧位）到3.6±6.7 mmHg（坐位），p = 0.46]。58%的坐位记录中出现自发性低频压力波动，其频率几乎是仰卧位的两倍（33%；p = 0.001），而未观察到对淋巴毛细血管网络扩张有影响（p = 0.12）。
使用伺服归零微压系统，可以直接评估姿势对IFP的影响。坐位时IFP较高，但差异受直立位时间的影响。
