Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Department of Otorhinolaryngology Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.
Sci Rep. 2020 Feb 21;10(1):3192. doi: 10.1038/s41598-020-60209-w.
Serum calcium, although only comprising 1% of total body calcium, is involved in intracellular signal pathways, vascular dilatation/constriction, and muscle contraction, which are crucial for insulin secretion, cholesterol catabolism, and blood pressure regulation. As far as we know, research on the relationship between serum calcium level and metabolic syndrome (MetS), diabetes, and hypertension in one longitudinal study is rare. Owing to the crucial role of serum calcium in human cardiometabolic physiology and lack of related study so far, this study aims to describe the relationship between serum calcium level and the incidence of MetS, diabetes, and hypertension. During the period 2010-2016, there are two parts to our study: cross-sectional analysis and longitudinal analysis. Logistic regression was applied for cross-sectional analysis of the association between serum calcium level or albumin-corrected calcium (ACCA) and the prevalence of MetS, diabetes, or hypertension. Receiver operating characteristic (ROC) curve analysis was used for calculating of optimal cut-off value of serum calcium and ACCA. Cox proportional regression for development of MetS, diabetes, and hypertension according to different cut-off values of serum calcium level and ACCA were conducted. At baseline, there were 27,364 participants in our study. Serum calcium level had positive association with diabetes in the total population, male, and female. ACCA level had positive association with diabetes in the total population, male, and female. In unadjusted and multivariate Cox proportional hazard models, serum calcium level was associated with increased risk of incident MetS in the total population and male. ACCA was associated with increased risk of incident MetS in the total population and male. ACCA was associated with increased risk of incident diabetes in the total population and male participants. This study describes the relationship between serum calcium level and the incidence of MetS, diabetes, and hypertension. Higher serum calcium level is associated with increased risk of MetS, diabetes, and hypertension.
血清钙虽然仅占体内总钙的 1%，但参与细胞内信号通路、血管舒张/收缩和肌肉收缩，这些过程对胰岛素分泌、胆固醇代谢和血压调节至关重要。据我们所知，在一项纵向研究中，关于血清钙水平与代谢综合征（MetS）、糖尿病和高血压之间关系的研究很少。由于血清钙在人类心脏代谢生理学中的关键作用，以及到目前为止缺乏相关研究，本研究旨在描述血清钙水平与 MetS、糖尿病和高血压的发生之间的关系。在 2010-2016 年期间，我们的研究分为两部分：横断面分析和纵向分析。应用逻辑回归进行横断面分析，以研究血清钙水平或白蛋白校正钙（ACCA）与 MetS、糖尿病或高血压患病率之间的关系。接收者操作特征（ROC）曲线分析用于计算血清钙和 ACCA 的最佳截断值。根据不同的血清钙水平和 ACCA 截断值，应用 Cox 比例风险回归分析 MetS、糖尿病和高血压的发展。在基线时，我们的研究中有 27364 名参与者。血清钙水平与全人群、男性和女性的糖尿病均呈正相关。ACCA 水平与全人群、男性和女性的糖尿病均呈正相关。在未调整和多变量 Cox 比例风险模型中，血清钙水平与全人群和男性发生 MetS 的风险增加相关。ACCA 与全人群和男性发生 MetS 的风险增加相关。ACCA 与全人群和男性参与者发生糖尿病的风险增加相关。本研究描述了血清钙水平与 MetS、糖尿病和高血压发生之间的关系。较高的血清钙水平与 MetS、糖尿病和高血压的风险增加相关。
