Jorde R, Sundsfjord J, Fitzgerald P, Bønaa K H
Department of Medicine, University Hospital of Tromsø, Norway.
Hypertension. 1999 Sep;34(3):484-90. doi: 10.1161/01.hyp.34.3.484.
Total serum calcium levels were measured in 12 865 men and 14 293 women, between the ages of 25 and 97 years, in the Tromsø Study during 1994 and 1995. With the use of a sex-specific multiple linear regression model with age, calcium, body mass index, cholesterol, HDL cholesterol, triglycerides, systolic and diastolic blood pressure, and pulse as possible covariates, serum calcium was significantly (P<0.001) and positively associated with systolic and diastolic blood pressure, serum cholesterol, and HDL cholesterol in both sexes. A similar but weaker association was observed between serum calcium and triglycerides in men (P<0.01). In all age groups, serum calcium levels were higher in men with a history of myocardial infarction than in those without, and the difference was significant (P<0.0001) in a linear regression analysis adjusted for age. When all the other variables were also included in a logistic regression model, serum calcium was a highly significant (P<0.0001) predictor of myocardial infarction in men, with an odds ratio of 1.2 per 0.1 mmol/L increase in serum calcium. In women, a nonsignificant trend was again seen. Because the free or ionized form of calcium is the physiologically important form and serum calcium was not corrected for serum albumin in our study, the results must be interpreted with caution. However, it appears likely that serum calcium is a predictor of cardiovascular disease in men.
1994年至1995年期间，在特罗姆瑟研究中，对12865名年龄在25岁至97岁之间的男性和14293名女性测量了血清总钙水平。在使用包含年龄、钙、体重指数、胆固醇、高密度脂蛋白胆固醇、甘油三酯、收缩压和舒张压以及脉搏作为可能协变量的性别特异性多元线性回归模型时，血清钙在两性中均与收缩压和舒张压、血清胆固醇以及高密度脂蛋白胆固醇显著（P<0.001）正相关。在男性中观察到血清钙与甘油三酯之间存在类似但较弱的关联（P<0.01）。在所有年龄组中，有心肌梗死病史的男性血清钙水平高于无心肌梗死病史的男性，在经年龄调整的线性回归分析中差异显著（P<0.0001）。当将所有其他变量也纳入逻辑回归模型时，血清钙是男性心肌梗死的高度显著（P<0.0001）预测因子，血清钙每升高0.1 mmol/L，比值比为1.2。在女性中，再次观察到无显著趋势。由于钙的游离或离子化形式是生理上重要的形式，且我们的研究中血清钙未校正血清白蛋白，因此对结果的解释必须谨慎。然而，血清钙似乎可能是男性心血管疾病的预测因子。
