Land J A, den Hartog J E
Department of Obstetrics and Gynecology, Research Institute Growth and Development, GROW, Academisch Ziekenhuis Maastricht, and Maastricht University, Maastricht, The Netherlands.
Drugs Today (Barc). 2006 Mar;42 Suppl A:35-42.
In the majority of women, Chlamydia trachomatis infections remain asymptomatic. These unrecognized and untreated infections may increase the risk for tubal factor subfertility at a later age. Since the association between C. trachomatis IgG antibodies in serum and tubal pathology was noticed, C. trachomatis IgG antibody testing has been used as a screening test for tubal factor subfertility. The diagnostic accuracy of C. trachomatis IgG antibody testing is limited, however. Since women who have persistent chlamydia infections are considered to be at the highest risk for developing late sequelae, the predictive value of markers of persistent infections have been studied in subfertile women. Patients who had C. trachomatis IgG antibodies (as markers of a previous infection), and an elevated C-reactive protein within the normal range (as a marker of a persisting infection) had the highest risk for having tubal pathology.
在大多数女性中，沙眼衣原体感染仍无症状。这些未被识别和未治疗的感染可能会增加日后输卵管因素导致的生育力低下的风险。自从血清中沙眼衣原体IgG抗体与输卵管病变之间的关联被发现以来，沙眼衣原体IgG抗体检测已被用作输卵管因素导致的生育力低下的筛查试验。然而，沙眼衣原体IgG抗体检测的诊断准确性有限。由于持续感染衣原体的女性被认为发生晚期后遗症的风险最高，因此在生育力低下的女性中研究了持续感染标志物的预测价值。有沙眼衣原体IgG抗体（作为既往感染的标志物）且C反应蛋白在正常范围内升高（作为持续感染的标志物）的患者发生输卵管病变的风险最高。
