Stemmer P, Klee C B
Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Curr Opin Neurobiol. 1991 Jun;1(1):53-64. doi: 10.1016/0959-4388(91)90010-5.
The cloning and sequence determination of cDNAs encoding different types of serine/threonine protein phosphatases has provided a molecular basis for the protein phosphatase classification proposed by Ingebritsen and Cohen. Each of the phosphatases, phosphatase-1, -2A, -2B and -2C, exists as multiple isozymes raising the possibility that isozymes selectively expressed in different tissues may perform specific functions. The recent discovery of potent toxin inhibitors specific for protein phosphatase-1 and -2A will undoubtedly play an important role in the elucidation of the role of these enzymes in neuronal function.
编码不同类型丝氨酸/苏氨酸蛋白磷酸酶的cDNA的克隆和序列测定，为英格布里森和科恩提出的蛋白磷酸酶分类提供了分子基础。磷酸酶-1、-2A、-2B和-2C中的每一种都以多种同工酶形式存在，这增加了在不同组织中选择性表达的同工酶可能执行特定功能的可能性。最近发现的对蛋白磷酸酶-1和-2A具有特异性的强效毒素抑制剂，无疑将在阐明这些酶在神经元功能中的作用方面发挥重要作用。
