生存素蛋白、PTEN在前列腺癌中的表达及意义
[Expression and significance of survivin protein, PTEN in prostatic cancer].
作者信息
Xia Xue-yan, Li Lian-hong, Li Xian-cheng, Jang Tao
机构信息
Department of Pathology, the First Affiliated Hospital, Dalian Medical University, Liaoning, China.
出版信息
Zhonghua Nan Ke Xue. 2006 Apr;12(4):346-8, 351.
OBJECTIVE
To study the expressions of survivin, PTEN and their relationships with tissue grade and pathology stage in prostatic carcinoma (PCa).
METHODS
The immunohistological staining was used to evaluated the expressions of survivin protein and PTEN in 43 case of prostatic carcinoma (PCa) and 5 cases of benign prostatic hyperplasia (BPH).
RESULTS
The positive rate of survivin protein was 81.40%. Expression of survivin protein in 5 case of BPH was negative. The positive rate of PTEN was 30.23%, and the higher the grade and the clinical stage of tumors were, the lower the expression of PTEN was, PTEN of 5 case of BPH was positive.
CONCLUSION
The positively correlation was found between the abnormal expressions of survivin protein, PTEN and the biological behavior of prostatic carcinoma (PCa). Detection of survivin combined with PTEN is valuable for diagnosing PCa, and evaluating malignancy extent and prognosis.
目的
研究survivin、PTEN在前列腺癌（PCa）中的表达及其与组织分级和病理分期的关系。
方法
采用免疫组织化学染色法检测43例前列腺癌（PCa）及5例良性前列腺增生（BPH）组织中survivin蛋白和PTEN的表达。
结果
survivin蛋白阳性率为81.40%。5例BPH组织中survivin蛋白表达均为阴性。PTEN阳性率为30.23%，肿瘤分级和临床分期越高，PTEN表达越低，5例BPH组织中PTEN均为阳性。
结论
survivin蛋白、PTEN的异常表达与前列腺癌（PCa）生物学行为呈正相关。联合检测survivin与PTEN对PCa诊断、评估恶性程度及预后有重要价值。
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