[FHIT与PTEN在前列腺癌中的表达及其意义]

[Expressions of FHIT and PTEN and their significance in prostate cancer].

作者信息

Xiao Qin, Gu Xue-wen, Jiang Ji-xin, Wang Cui-mei, Xu Qing

机构信息

Department of Pathology, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu 225001, China.

出版信息

Zhonghua Nan Ke Xue. 2011 Feb;17(2):136-9.

PMID:21404710

Abstract

OBJECTIVE

To investigate the expressions of the FHIT and PTEN genes and their significance in prostate cancer.

METHODS

The expressions of FHIT and PTEN were detected in 85 cases of prostate cancer and 30 cases of benign prostatic nodular hyperplasia by immunohistochemistry of PV-6000.

RESULTS

The positive expression rates of FHIT and PTEN were 34.1% and 42.4% in prostate cancer, significantly lower than 96.7% and 90.0% in benign prostatic nodular hyperplasia (P <0.01). Statistically significant differences were found in the positive expression rates of FHIT and PTEN among different Gleason grades, 44.4% and 55.6% in well differentiated, 38.9% and 44.4% in moderately differentiated, and 25.0% and 37.5% in lowly differentiated prostate cancer (P <0.05). But the expression of FHIT.

CONCLUSION

FHIT and PTEN may play a certain role in the was not correlated with that of PTEN in the prostate cancer tissue (P >0.05). development, progression and infiltration of prostate cancer.

摘要

目的

探讨FHIT和PTEN基因在前列腺癌中的表达及其意义。

方法

采用PV - 6000免疫组织化学法检测85例前列腺癌及30例良性前列腺结节增生组织中FHIT和PTEN的表达。

结果

前列腺癌中FHIT和PTEN的阳性表达率分别为34.1%和42.4%，显著低于良性前列腺结节增生中的96.7%和90.0%（P<0.01）。不同Gleason分级的前列腺癌中，FHIT和PTEN的阳性表达率存在统计学差异，高分化前列腺癌中分别为44.4%和55.6%，中分化为38.9%和44.4%，低分化为25.0%和37.5%（P<0.05）。但在前列腺癌组织中，FHIT的表达与PTEN的表达无相关性（P>0.05）。