利用ψ分析表征蛋白质折叠过渡态。 - Suppr

Characterizing the protein folding transition state using psi analysis.

作者信息

Sosnick Tobin R, Krantz Bryan A, Dothager Robin S, Baxa Michael

机构信息

Department of Biochemistry, Institute for Biophysical Dynamics, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA.

出版信息

Chem Rev. 2006 May;106(5):1862-76. doi: 10.1021/cr040431q.

DOI:10.1021/cr040431q

PMID:16683758

Abstract

摘要

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Characterizing the protein folding transition state using psi analysis.利用ψ分析表征蛋白质折叠过渡态。

Chem Rev. 2006 May;106(5):1862-76. doi: 10.1021/cr040431q.

Interpretation of protein folding psi values.蛋白质折叠ψ值的解读

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Discerning the structure and energy of multiple transition states in protein folding using psi-analysis.使用ψ分析识别蛋白质折叠中多个过渡态的结构和能量。

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Determination of the transition state ensemble for the folding of ubiquitin from a combination of Phi and Psi analyses.通过Phi和Psi分析相结合确定泛素折叠的过渡态系综。

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Folding of circular permutants with decreased contact order: general trend balanced by protein stability.接触顺序降低的环状置换突变体的折叠：由蛋白质稳定性平衡的总体趋势

J Mol Biol. 2001 Dec 7;314(4):891-900. doi: 10.1006/jmbi.2001.5186.

Small proteins fold through transition states with native-like topologies.小蛋白质通过具有类似天然拓扑结构的过渡态进行折叠。

J Mol Biol. 2006 Aug 25;361(4):755-70. doi: 10.1016/j.jmb.2006.06.041. Epub 2006 Jul 7.

Design of beta-sheet systems for understanding the thermodynamics and kinetics of protein folding.用于理解蛋白质折叠热力学和动力学的β-折叠系统设计

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Thermodynamics and kinetics of a Gō proteinlike heteropolymer model with two-state folding characteristics.具有两态折叠特征的类Gō蛋白异聚物模型的热力学与动力学

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Sequential barriers and an obligatory metastable intermediate define the apparent two-state folding pathway of the ubiquitin-like PB1 domain of NBR1.连续的屏障和一个必需的亚稳态中间体定义了NBR1的泛素样PB1结构域明显的两态折叠途径。

J Mol Biol. 2008 Mar 7;376(5):1463-77. doi: 10.1016/j.jmb.2007.12.052. Epub 2008 Jan 3.

A new folding paradigm for repeat proteins.重复蛋白的一种新折叠模式。

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Residue-based correlation between equilibrium and rate constants is an experimental formulation of the consistency principle for smooth structural changes of proteins.基于残基的平衡常数与速率常数之间的相关性是蛋白质平滑结构变化一致性原理的一种实验表述。

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Mutational Analysis of Protein Folding Transition States: Phi Values.蛋白质折叠转变态的突变分析：Φ 值。

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The consequences of cavity creation on the folding landscape of a repeat protein depend upon context.腔的形成对重复蛋白折叠景观的影响取决于环境。

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Cooperative folding near the downhill limit determined with amino acid resolution by hydrogen exchange.通过氢交换以氨基酸分辨率确定的下坡极限附近的协同折叠。

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Microscopic interpretation of folding ϕ-values using the transition path ensemble.使用过渡路径系综对折叠φ值进行微观解释。

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Even with nonnative interactions, the updated folding transition states of the homologs Proteins G & L are extensive and similar.即使存在非天然相互作用，同源蛋白G和L更新后的折叠过渡态也是广泛且相似的。

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Modulation of folding energy landscape by charge-charge interactions: linking experiments with computational modeling.通过电荷-电荷相互作用对折叠能量景观的调控：将实验与计算建模相联系。

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Characterizing the protein folding transition state using psi analysis.

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