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人类免疫缺陷病毒和丙型肝炎病毒合并感染的血友病患者:骨科治疗的最佳选择有哪些?

HIV and HCV coinfected haemophilia patients: what are the best options of orthopaedic treatment?

作者信息

Rodriguez-Merchan E C

机构信息

Service of Orthopaedics and Traumatology and Haemophilia Unit, La Paz University Hospital, Madrid, Spain.

出版信息

Haemophilia. 2006 Jul;12 Suppl 3:90-101. doi: 10.1111/j.1365-2516.2006.01264.x.

Abstract

In the era of contemporary orthopaedics, haematology and internal medicine, it is obvious that surgery can be indicated in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfected haemophilia patients suffering from severe and painful musculoskeletal problems. However, the expected high risk of infection and other postoperative complications is a concern due to the poor health status that many of these patients present. In a HIV and HCV coinfected haemophilia patient, the orthopaedic surgeon together with the multidisciplinary haemophilia team should weigh the risks and benefits carefully. Clinical and immunological status should be considered before suggesting a surgical procedure (specially a joint arthroplasty) in this group of patients. If a surgical procedure is contraindicated, conservative treatment could be an alternative, although many times with inferior results. Usually, surgical procedures can better relieve pain for several years and improve the quality of life in this cohort of patients. Regarding anaesthetics, drugs metabolized by the liver or the kidney should be avoided depending on every particular case. Rachianaesthesia is more recommendable than epidural anaesthesia in elderly patients in whom general anaesthesia sometimes could be dangerous, although in all ages we prefer general anaesthesia. The size of the needle should be small (size G-27), and we never use spinal catheters.

摘要

在当代骨科、血液学和内科时代,显而易见的是,对于合并感染人类免疫缺陷病毒(HIV)和丙型肝炎病毒(HCV)且患有严重疼痛性肌肉骨骼问题的血友病患者,可以考虑进行手术。然而,由于这些患者中许多人的健康状况不佳,预期的高感染风险和其他术后并发症令人担忧。对于合并感染HIV和HCV的血友病患者,骨科医生应与多学科血友病团队一起仔细权衡风险和益处。在为这类患者建议进行手术(特别是关节置换术)之前,应考虑临床和免疫状况。如果手术禁忌,保守治疗可能是一种选择,尽管很多时候效果较差。通常,手术可以在数年内更好地缓解疼痛并改善这类患者的生活质量。关于麻醉,应根据具体情况避免使用经肝脏或肾脏代谢的药物。在老年患者中,蛛网膜下腔麻醉比硬膜外麻醉更值得推荐,全身麻醉有时对老年患者可能有危险,尽管在所有年龄段我们都更倾向于全身麻醉。针头尺寸应较小(G - 27号),并且我们从不使用脊髓导管。

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