Fisher Charles G, Noonan Vanessa K, Dvorak Marcel F
Combined Neurosurgical and Orthopaedic Spine Program, Department of Orthopaedics, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada.
Spine (Phila Pa 1976). 2006 May 15;31(11 Suppl):S2-8; discussion S36. doi: 10.1097/01.brs.0000217948.02567.3a.
An evidence-based review and summary of literature from multiple disciplines involved in spine trauma.
To outline epidemiologic, clinical, and research issues influencing spine trauma in a longitudinal perspective. In addition, to provide guidance to clinicians and researchers to ensure that philosophies pertaining to the betterment of spine trauma care are understood and supported.
Epidemiologic data have provided insight into future demands the elderly patient with spine injury will place on the health care system. Regional trauma programs have emerged with further specialization resulting in regionalized spine trauma care. Evidence-based guidelines have streamlined imaging, and biomaterial advancements have facilitated the stabilization of the spinal column and decompression of the spinal cord. Promising experimental therapies promoting axonal regeneration and neuroprotective agents are beginning clinical trials, generating cautious optimism that effective therapies for spinal cord injuries will emerge. The unsustainable economics of increasing technology and patient expectations will make economic evaluation critical.
Evidence-based review of current literature and expert opinion.
Multicenter spine trauma registries with patient-reported outcomes will allow many questions around spine trauma to be answered using the highest levels of evidence. This process in synergy with technical and biologic developments should ensure progress toward optimal care of the spine trauma patient. Future challenges will be to treat the breadth and magnitude of the discoveries within the fiscal restraints of the health care system and ensure its affordability for society.
对涉及脊柱创伤的多个学科的文献进行基于证据的综述和总结。
从纵向角度概述影响脊柱创伤的流行病学、临床和研究问题。此外,为临床医生和研究人员提供指导,以确保与改善脊柱创伤护理相关的理念得到理解和支持。
流行病学数据为了解老年脊柱损伤患者未来对医疗保健系统的需求提供了见解。区域创伤项目已经出现,且进一步专业化,从而形成了区域化的脊柱创伤护理。基于证据的指南简化了影像学检查,生物材料的进步促进了脊柱的稳定和脊髓减压。促进轴突再生的有前景的实验性疗法和神经保护剂正在开始临床试验,这引发了谨慎的乐观情绪,即有望出现治疗脊髓损伤的有效疗法。技术和患者期望不断增加所带来的不可持续的经济问题将使经济评估变得至关重要。
对当前文献和专家意见进行基于证据的综述。
具有患者报告结局的多中心脊柱创伤登记将使围绕脊柱创伤的许多问题能够通过最高水平的证据得到解答。这一过程与技术和生物学发展协同作用,应确保在脊柱创伤患者的最佳护理方面取得进展。未来的挑战将是在医疗保健系统的财政限制内应对发现的广度和规模,并确保社会能够承受。