复方口服避孕药的使用会导致年轻女性鼻腔生理发生变化吗？
Does the use of the combined oral contraceptive pill cause changes in the nasal physiology in young women?
作者信息
Wolstenholme Charlotte R, Philpott Carl M, Oloto Emeka J, Murty George E
机构信息
Department of Otorhinolaryngology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
出版信息
Am J Rhinol. 2006 Mar-Apr;20(2):238-40.
BACKGROUND
Changes in nasal physiology have been observed during pregnancy and the menstrual cycle. The role of female hormones in these changes is unclear. The aim is to investigate the effect of the modern combined oral contraceptive pill (COCP).
METHODS
Eleven women were recruited from a family planning clinic. Anterior rhinoscopy, peak inspiratory flow rate, acoustic rhinometry, anterior rhinomanometry, mucociliary clearance time, and rhinitis quality-of-life questionnaire (RQLQ) scores were recorded at days 1 and 14 pre- and post-COCP.
RESULTS
Increased nasal obstruction midcycle pre-COCP, with significant differences for anterior rhinoscopy (p = 0.001) and peak inspiratory flow rate (p = 0.022), was found. No statistical difference was shown between pre- and post-COCP results apart from day 1 anterior rhinoscopy findings (p = 0.05).
CONCLUSION
The modern COCP has no significant effect on nasal physiology.
背景
在孕期和月经周期中观察到了鼻腔生理变化。女性激素在这些变化中的作用尚不清楚。目的是研究现代复方口服避孕药（COCP）的作用。
方法
从一家计划生育诊所招募了11名女性。在服用COCP前1天和第14天以及服用后1天和第14天记录前鼻镜检查、吸气峰流速、鼻声反射、前鼻测压、黏液纤毛清除时间和鼻炎生活质量问卷（RQLQ）评分。
结果
发现服用COCP前月经周期中期鼻塞增加，前鼻镜检查（p = 0.001）和吸气峰流速（p = 0.022）有显著差异。除了第1天的前鼻镜检查结果外（p = 0.05），服用COCP前后的结果没有统计学差异。
结论
现代COCP对鼻腔生理没有显著影响。
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