使用光不稳定氨基酸单体进行光导向无掩膜肽阵列合成。

Light-directed maskless synthesis of peptide arrays using photolabile amino acid monomers.

作者信息

Bhushan Kumar R

机构信息

Division of Hematology/Oncology, SL-B10, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA.

出版信息

Org Biomol Chem. 2006 May 21;4(10):1857-9. doi: 10.1039/b601390b. Epub 2006 Apr 12.

DOI:10.1039/b601390b

PMID:16688328

Abstract

Novel photolabile amino acid monomers for photolithographic solid-phase peptide synthesis has been developed and a method for the maskless synthesis of individually addressable peptide microarrays using new building blocks has been described; these peptide microarrays are suitable for repetitive epitope-binding assays.

摘要

已开发出用于光刻固相肽合成的新型光不稳定氨基酸单体，并描述了一种使用新构建模块无掩膜合成可单独寻址肽微阵列的方法；这些肽微阵列适用于重复性表位结合测定。