Bode Ann M, Dong Zigang
The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA.
Mol Carcinog. 2006 Jun;45(6):422-30. doi: 10.1002/mc.20222.
Carcinogenesis is a multistage process consisting of initiation, promotion, and progression stages and each stage may be a possible target for chemopreventive agents. A significant outcome of these investigations on the elucidation of molecular and cellular mechanisms is the explication of signal transduction pathways induced by tumor promoters in cancer development. The current belief today is that cancer may be prevented or treated by targeting specific cancer genes, signaling proteins, and transcription factors. The molecular mechanisms explaining how normal cells undergo neoplastic transformation induced by tumor promoters are rapidly being clarified. Accumulating research evidence suggests that many of dietary factors, including tea compounds, may be used alone or in combination with traditional chemotherapeutic agents to prevent or treat cancer. The potential advantage of many natural or dietary compounds seems to focus on their potent anticancer activity combined with low toxicity and very few adverse side effects. This review summarizes some of our recent work regarding the effects of the various tea components on signal transduction pathways involved in neoplastic cell transformation and carcinogenesis.
致癌作用是一个多阶段过程，包括启动、促进和进展阶段，每个阶段都可能是化学预防剂的潜在作用靶点。这些关于阐明分子和细胞机制的研究的一个重要成果是对肿瘤促进剂在癌症发展过程中诱导的信号转导通路的阐释。目前的观点认为，通过靶向特定的癌症基因、信号蛋白和转录因子，可以预防或治疗癌症。解释肿瘤促进剂如何诱导正常细胞发生肿瘤转化的分子机制正在迅速得到阐明。越来越多的研究证据表明，许多饮食因素，包括茶叶成分，可单独使用或与传统化疗药物联合使用来预防或治疗癌症。许多天然或饮食化合物的潜在优势似乎在于它们强大的抗癌活性，同时毒性低且几乎没有不良副作用。本综述总结了我们最近关于各种茶叶成分对肿瘤细胞转化和致癌过程中涉及的信号转导通路影响的一些研究工作。
