Department of Seafood Science, National Kaohsiung Marine University, No.142, Haijhuan Rd., Nanzih District, Kaohsiung 81143, Taiwan.
Food Funct. 2011 Feb;2(2):101-10. doi: 10.1039/c0fo00174k. Epub 2011 Jan 18.
The consumption of green tea has long been associated with a reduced risk of cancer development. (-)-Epicatechin-3-gallate (ECG) or (-)-epigallocatechin-3-gallate (EGCG) are the major antioxidative polyphenolic compounds of green tea. They have been shown to exert growth-inhibitory potential of various cancer cells in culture and antitumor activity in vivo models. ECG or EGCG could interact with various molecules like proteins, transcription factors, and enzymes, which block multiple stages of carcinogenesis via regulating intracellular signaling transduction pathways. Moreover, ECG and EGCG possess pharmacological and physiological properties including induction of phase II enzymes, mediation of anti-inflammation response, regulation of cell proliferation and apoptosis effects and prevention of tumor angiogenesis, invasion and metastasis. Numerous review articles have been focused on EGCG, however none have been focused on ECG despite many studies supporting the cancer preventive potential of ECG. To develop ECG as an anticarcinogenic agent, more clear understanding of the cell signaling pathways and the molecular targets responsible for chemopreventive and chemotherapeutic effects are needed. This review summarizes recent research on the ECG-induced cellular signal transduction events which implicate in cancer management.
绿茶的消费长期以来与癌症发展风险的降低有关。(-)-表没食子儿茶素-3-没食子酸酯 (ECG) 或 (-)-表儿茶素-3-没食子酸酯 (EGCG) 是绿茶中主要的抗氧化多酚化合物。它们已被证明在培养的各种癌细胞中具有生长抑制潜力，并在体内肿瘤模型中具有抗肿瘤活性。ECG 或 EGCG 可与多种分子相互作用，如蛋白质、转录因子和酶，通过调节细胞内信号转导途径来阻断致癌作用的多个阶段。此外，ECG 和 EGCG 具有药理学和生理学特性，包括诱导 II 相酶、介导抗炎反应、调节细胞增殖和凋亡作用以及预防肿瘤血管生成、侵袭和转移。许多综述文章都集中在 EGCG 上，但是尽管有许多研究支持 ECG 在预防癌症方面的潜力，但没有一篇文章集中在 ECG 上。为了将 ECG 开发为一种抗癌剂，需要更清楚地了解负责化学预防和化学治疗作用的细胞信号通路和分子靶标。本文综述了 ECG 诱导的细胞信号转导事件的最新研究进展，这些事件与癌症的管理有关。
