Evins A E, Amico E T, Shih V, Goff D C
Psychotic Disorders Program, Massachusetts General Hospital, Boston, USA.
J Neural Transm (Vienna). 1997;104(6-7):761-6. doi: 10.1007/BF01291892.
To examine whether serum excitatory amino acid concentrations change with clozapine treatment and whether these changes correlate with improvement in negative symptoms, serum excitatory amino acids were measured and clinical scales administered in seven subjects with schizophrenia before and after switching from conventional neuroleptics to clozapine. Clozapine treatment was associated with increased serum glutamate and aspartate concentrations. Clinical improvement was negatively correlated with baseline glycine concentrations. These results support the hypothesis that clozapine acts at least in part by increasing glutamatergic activity.
为了研究血清兴奋性氨基酸浓度是否会随氯氮平治疗而变化，以及这些变化是否与阴性症状的改善相关，我们对7名精神分裂症患者在从传统抗精神病药物换用氯氮平之前和之后测量了血清兴奋性氨基酸，并进行了临床量表评估。氯氮平治疗与血清谷氨酸和天冬氨酸浓度升高有关。临床改善与基线甘氨酸浓度呈负相关。这些结果支持了氯氮平至少部分通过增加谷氨酸能活性起作用的假说。
