一组人类免疫缺陷病毒感染患者的周围神经病变。发病率及其与其他神经系统功能障碍的关系。

Peripheral neuropathy in a cohort of human immunodeficiency virus-infected patients. Incidence and relationship to other nervous system dysfunction.

作者信息

Hall C D, Snyder C R, Messenheimer J A, Wilkins J W, Robertson W T, Whaley R A, Robertson K R

机构信息

AIDS Neurologic Center, University of North Carolina School of Medicine, Chapel Hill 27599-7025.

出版信息

Arch Neurol. 1991 Dec;48(12):1273-4. doi: 10.1001/archneur.1991.00530240077026.

DOI:10.1001/archneur.1991.00530240077026

PMID:1668978

Abstract

A cohort of 94 patients infected with human immunodeficiency virus was evaluated clinically and electrophysiologically for the presence of peripheral neuropathy, and the results were compared with evaluations of central nervous system function. Thirty-two (34%) had some degree of peripheral neuropathy; 18 (19%) (six [12%] of the 49 asymptomatic patients, five [45%] of the 11 patients with acquired immunodeficiency syndrome [AIDS], and seven [21%] of the 34 patients with AIDS-related complex) had neuropathy on clinical examination; and 21 (23%) (eight [16%] asymptomatic, four [36%] AIDS, and nine [26%] AIDS-related complex) had neuropathy on electrophysiologic evaluation. There was a significant correlation between the presence of neuropathy and evidence of central nervous system dysfunction.

摘要

对94例感染人类免疫缺陷病毒的患者进行了临床和电生理评估，以确定是否存在周围神经病变，并将结果与中枢神经系统功能评估结果进行比较。32例（34%）有一定程度的周围神经病变；18例（19%）（49例无症状患者中的6例[12%]、11例获得性免疫缺陷综合征[艾滋病]患者中的5例[45%]、34例艾滋病相关综合征患者中的7例[21%]）经临床检查有神经病变；21例（23%）（无症状患者中的8例[16%]、艾滋病患者中的4例[36%]、艾滋病相关综合征患者中的9例[26%]）经电生理评估有神经病变。神经病变的存在与中枢神经系统功能障碍的证据之间存在显著相关性。