Shu-Chi Mu, Jiann-Loung Hwang, Yu-Hung Lin, Tseng-Chen Sung, Ming-I Lin, Tsu-Fuh Yeh
Institiute of Clinical Medicine, National Yang-Ming University, Medical College of Fu-Jen University, Taiwan.
Early Hum Dev. 2006 Oct;82(10):677-82. doi: 10.1016/j.earlhumdev.2006.01.012. Epub 2006 May 11.
The objective of this study is to evaluate the physical and mental development of infants born on in-vitro maturation (IVM) programs.
We compare 21 IVM children as study group and 21 non-IVM children as control group. We performed a general physical examination for malformations, neurological examination, developmental examination (Bayley Scales) on the IVM group and the non-IVM group.
We found all the children with normal karyotype and without major malformation in both IVM and non-IVM groups. The mean Mental Development Index scores for IVM subjects and the comparison group were 92.71+/-10.47 and 97.19+/-8.88, respectively (p=0.074). The mean Psychomotor Development Index scores were 96.67+/-8.91 and 96.19+/-7.05, respectively (p=0.817).
This is the first study designed to evaluate the physical growth and developmental indices of IVM children with combinational priming protocol of FSH and hCG. Our results suggest that IVM children didn't show developmental delay during infancy and early childhood.
本研究的目的是评估通过体外成熟（IVM）程序出生的婴儿的身心发育情况。
我们将21名IVM儿童作为研究组，21名非IVM儿童作为对照组。我们对IVM组和非IVM组进行了畸形的一般体格检查、神经学检查、发育检查（贝利量表）。
我们发现IVM组和非IVM组的所有儿童核型均正常且无重大畸形。IVM组受试者和对照组的平均智力发育指数得分分别为92.71±10.47和97.19±8.88（p = 0.074）。平均心理运动发育指数得分分别为96.67±8.91和96.19±7.05（p = 0.817）。
这是第一项旨在评估采用FSH和hCG联合启动方案的IVM儿童身体生长和发育指标的研究。我们的结果表明，IVM儿童在婴儿期和幼儿期未表现出发育延迟。
