Xing Lei, Thorndyke Brian, Schreibmann Eduard, Yang Yong, Li Tian-Fang, Kim Gwe-Ya, Luxton Gary, Koong Albert
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305-5847, USA.
Med Dosim. 2006 Summer;31(2):91-112. doi: 10.1016/j.meddos.2005.12.004.
Radiation therapy has gone through a series of revolutions in the last few decades and it is now possible to produce highly conformal radiation dose distribution by using techniques such as intensity-modulated radiation therapy (IMRT). The improved dose conformity and steep dose gradients have necessitated enhanced patient localization and beam targeting techniques for radiotherapy treatments. Components affecting the reproducibility of target position during and between subsequent fractions of radiation therapy include the displacement of internal organs between fractions and internal organ motion within a fraction. Image-guided radiation therapy (IGRT) uses advanced imaging technology to better define the tumor target and is the key to reducing and ultimately eliminating the uncertainties. The purpose of this article is to summarize recent advancements in IGRT and discussed various practical issues related to the implementation of the new imaging techniques available to radiation oncology community. We introduce various new IGRT concepts and approaches, and hope to provide the reader with a comprehensive understanding of the emerging clinical IGRT technologies. Some important research topics will also be addressed.
在过去几十年里，放射治疗经历了一系列变革，如今通过使用诸如调强放射治疗（IMRT）等技术，已能够产生高度适形的放射剂量分布。剂量适形性的改善和陡峭的剂量梯度使得放射治疗中患者定位和射束靶向技术得到了加强。在放射治疗后续分次治疗期间及之间影响靶区位置可重复性的因素包括分次治疗之间内部器官的位移以及一次分次治疗内内部器官的运动。图像引导放射治疗（IGRT）使用先进的成像技术来更好地界定肿瘤靶区，是减少并最终消除不确定性的关键。本文的目的是总结IGRT的最新进展，并讨论与放射肿瘤学界可用的新成像技术实施相关的各种实际问题。我们介绍各种新的IGRT概念和方法，希望能让读者全面了解新兴的临床IGRT技术。还将探讨一些重要的研究课题。
