Król E, Rutkowski B, Manitius J, Manitius A, Sałek J, Wróblewska M, Lysiak-Szydłowska W
Kliniki Chorób Nerek, Gdańsku.
Pol Tyg Lek. 1991;46(32-34):614-6.
An effect of carnitine (Bicarnesine) on lipid metabolism in 14 patients treated with prolonged dialyses has been analysed. Carnitine has been administered orally in the dose of 30 mg/kg b.w. three times per week for 8 weeks and every day for the next 8 weeks. Carnitine, total triglycerides, total and HDL cholesterol, and glucose have been determined in serum. Blood lipoproteins have been assayed with electrophoresis in agarose gel. Total and free carnitine concentrations increased by 3.5 times within 16 weeks. Triglycerides level did not change significantly in all examined patients except a group of 6 patients with baseline hypertriglyceridemia, in which a significant but transient decrease in triglycerides level has been noted after 4 weeks of treatment. At the same time, normalization of blood lipoproteins has been observed. In the eighth week, a transient decrease in HDL-cholesterol has been noted. Result suggest, that carnitine despite an increase in total and free carnitine blood levels did not regulate lipid metabolism disorders. Moreover, its administration to patients treated with prolonged dialyses seems to be unfavourable due to several adverse reactions.
分析了肉碱（双肉碱）对14例长期接受透析治疗患者脂质代谢的影响。肉碱以30mg/kg体重的剂量口服，每周3次，共8周，随后8周每天服用。测定了血清中的肉碱、总甘油三酯、总胆固醇和高密度脂蛋白胆固醇以及葡萄糖。采用琼脂糖凝胶电泳法检测血脂蛋白。在16周内，总肉碱和游离肉碱浓度增加了3.5倍。除一组6例基线高甘油三酯血症患者外，所有受检患者的甘油三酯水平均无显著变化，其中治疗4周后甘油三酯水平出现显著但短暂的下降。同时，观察到血脂蛋白正常化。在第8周，观察到高密度脂蛋白胆固醇短暂下降。结果表明，尽管血液中总肉碱和游离肉碱水平升高，但肉碱并未调节脂质代谢紊乱。此外，由于一些不良反应，对长期透析治疗的患者给药似乎是不利的。
