Lubiniecki A S, Cypess R H
Infect Immun. 1975 Jun;11(6):1306-11. doi: 10.1128/iai.11.6.1306-1311.1975.
Immunosuppression of the antibody response to Japanese B encephalitis (JBE) virus and sheep erythrocytes (SRBC) was observed in mice infected with Trichinella spiralis. This suppression was paralleled by the presence of fewer antibody-forming cells to SRBC in the spleens of parasitized mice. Both primary and secondary complement-fixing antibody responses to JBE virus were suppressed, but the development of immunological memory was not affected. Parasitized mice demonstrated a normal blastogenic response to phytohemagglutinin and normal serum clearance rate of injected (125)I-labeled immunoglobulin G(2b), although the size of the extravascular fluid compartment was significantly increased. The data presented here and in previous reports suggest that sequential antigenic competition is a possible explanation for the humoral immunosuppression to heterologous antigens caused by T. spiralis infection.
在感染旋毛虫的小鼠中,观察到对日本乙型脑炎(JBE)病毒和绵羊红细胞(SRBC)的抗体反应受到免疫抑制。这种抑制与受寄生虫感染小鼠脾脏中针对SRBC的抗体形成细胞数量减少同时出现。对JBE病毒的原发性和继发性补体结合抗体反应均受到抑制,但免疫记忆的发展未受影响。受寄生虫感染的小鼠对植物血凝素表现出正常的增殖反应,对注射的(125)I标记免疫球蛋白G(2b)的血清清除率正常,尽管血管外液腔的大小显著增加。此处呈现的数据以及先前报告中的数据表明,顺序抗原竞争可能是旋毛虫感染导致对异源抗原体液免疫抑制的一种解释。