Hemalatha S, Wahi A K, Singh P N, Chansouria J P N
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221005, India.
Phytother Res. 2006 Jul;20(7):614-7. doi: 10.1002/ptr.1916.
Administration of an aqueous extract of fruits of Withania coagulans (1 g/kg; p.o.) to high fat diet induced hyperlipidemic rats for 7 weeks, significantly reduced elevated serum cholesterol, triglycerides and lipoprotein levels. This drug also showed hypolipidemic activity in triton induced hypercholesterolemia. The histopathological examination of liver tissues of treated hyperlipidemic rats showed comparatively lesser degenerative changes compared with hyperlipidemic controls. The hypolipidemic effect of W. coagulans fruits was found to be comparable to that of an Ayurvedic product containing Commiphora mukkul.
给高脂饮食诱导的高脂血症大鼠口服匙羹藤果实水提取物（1克/千克），持续7周，可显著降低升高的血清胆固醇、甘油三酯和脂蛋白水平。该药物在 Triton 诱导的高胆固醇血症中也表现出降血脂活性。与高脂血症对照组相比，经治疗的高脂血症大鼠肝脏组织的组织病理学检查显示变性变化相对较少。发现匙羹藤果实的降血脂作用与一种含有没药的阿育吠陀产品相当。
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